12/31/2023 0 Comments Ning jing xiaozhuang mishiCycling hypoxia monitoring in cells and zebrafish embryos is realized by HDSF using confocal imaging. Mass spectroscopic and theoretical studies confirm that the reversible sensing behavior is attributed to the two electron-withdrawing trifluoromethyl groups, which stabilizes the reduction intermediate phenylhydrazine and blocks the further reductive decomposition. HDSF displays an off-on fluorescence switch at 705 nm in normoxia-hypoxia cycles. Here we report a reversible arylazo-conjugated fluorescent probe (HDSF) for cycling hypoxia imaging. However, almost all of the reported organic fluorescent hypoxia probes reported until now were irreversible. NIR luminescent probes with negligible photocytotoxicity are required for long-term tracking of cycling hypoxia in vivo. 9 State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, China. 8 Model Animal Research Center, Nanjing University, Nanjing, China.
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